Affective resonance in response to others' emotional faces varies with affective ratings and psychopathic traits in amygdala and anterior insula

Despite extensive research on the neural basis of empathic responses for pain and disgust, there is limited data about the brain regions that underpin affective response to other people's emotional facial expressions. Here, we addressed this question using event-related functional magnetic resonance imaging to assess neural responses to emotional faces, combined with online ratings of subjective state. When instructed to rate their own affective response to others' faces, participants recruited anterior insula, dorsal anterior cingulate, inferior frontal gyrus, and amygdala, regions consistently implicated in studies investigating empathy for disgust and pain, as well as emotional saliency. Importantly, responses in anterior insula and amygdala were modulated by trial-by-trial variations in subjective affective responses to the emotional facial stimuli. Furthermore, overall task-elicited activations in these regions were negatively associated with psychopathic personality traits, which are characterized by low affective empathy. Our findings suggest that anterior insula and amygdala play important roles in the generation of affective internal states in response to others' emotional cues and that attenuated function in these regions may underlie reduced empathy in individuals with high levels of psychopathic traits.
This work was supported by the Portuguese Foundation for Science and Technology (Fundação para a Ciencia e Tecnologia) under grant number [SFRH/BD/60279/2009] awarded to A.S.C.; the Economic and Social Research Council under grant number [RES-062-23-2202] award to E.V; E.V. is a Royal Society Wolfson Research Merit Award holder; C.L.S. was partially supported during the writing of this article by an Economic and Social Research Council award [ES/K008951/1]; J.P.R. is funded by the Wellcome Trust.