Psychopathology and behavior problems in children and adolescents with Williams syndrome: distinctive relationships with cognition

Several studies have documented the high prevalence of psychopathology and behavior problems in Williams syndrome (WS). However, the links between cognitive development and such symptoms need further clarification. Our study aims to expand current knowledge on levels of behavior problems and its links to cognition in a sample of Brazilian individuals with WS. A total of 25 children and adolescents with WS and their parents participated in this study. The participants' IQs were assessed with the Wechsler Scales of Intelligence (for children or adults) and parental reports of psychopathology/behavior problems were collected using the Child Behavior Checklist (CBCL). The presence of clinically significant attention problems was a main feature in our sample of children and adolescents with WS. In the children, higher IQ scores were found to be significantly associated with less externalizing problems, while in the adolescents cognitive abilities were found to be associated with less internalizing symptoms. These results provide further insight into the links between psychopathology and behavior problems and cognitive abilities in WS, and suggest the need to take age into consideration when analyzing such relationships.
This work was supported by CAPES [grant numbers BEX 1551/08-6 and BEX 9573/11-9]; CNPq [grant numbers 308540/2012-3 and 487188/2013-6]; and FEDER through the Competitive Factors Operational Programme (COMPETE) and national funds from the Portuguese Foundation for Science and Technology [grant number PTDC/PSI-PCL/115316/2009].
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